Anti-CA9 Antibody

Rs. 45,619.00
SKU stj115637

General Information

Product name Anti-CA9 Antibody
Short Description Rabbit polyclonal to CA9
Description Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Carbonic anhydrase 9
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 52-151 of human CA9 (NP_001207.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 49.7 kDa
Database Links
Alternative Names CA9Carbonic anhydrase 9 CA9 antibodyG250 antibodyMN
Function Reversible hydration of carbon dioxide, Participates in pH regulation, May be involved in the control of cell proliferation and transformation, Appears to be a novel specific biomarker for a cervical neoplasia.
Cellular Localization Nucleus.
Tissue Specificity Expressed primarily in carcinoma cells lines, expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa
Swiss-Prot Key

 

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