General Information
| Product name | Anti-CADM1 Antibody |
|---|---|
| Short Description | Rabbit polyclonal to CADM1 |
| Description | |
| Applications | WB |
| Dilution range | WB 1:500 - 1:2000 |
| Protein Name | Anti-CADM1 Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 45-344 of human CADM1 (NP_001091987.1). |
| Storage Instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Isotype | IgG |
| Formulation | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 48.5 kDa |
| Database Links | |
| Alternative Names | CADM1Cell adhesion molecule 1 antibodyImmunoglobulin superfamily member 4 antibodyIgSF4 antibodyNectin-like protein 2 antibodyNECL-2 antibodySpermatogenic immunoglobulin superfamily antibodySgIgSF antibodySynaptic cell adhesion molecule antibodySynCAM antibodyTumor suppressor in lung cancer 1 antibodyTSLC-1CADM1 antibodyIGSF4 antibodyIGSF4A antibodyNECL2 antibodySYNCAM antibodyTSLC1 |
| Function | Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner, Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner, Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells, Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo, May contribute to the less invasive phenotypes of lepidic growth tumor cells, In mast cells, may mediate attachment to and promote communication with nerves, CADM1, together with MITF, is essential for development and survival of mast cells in vivo, Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity), May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons, May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. |
| Cellular Localization | Cell membrane |
| Tissue Specificity | |
| Swiss-Prot Key |