General Information
| Product name | Anti-Caldesmon antibody |
|---|---|
| Short Description | |
| Description | Rabbit polyclonal to Caldesmon. |
| Applications | WB,IHC,IF,ELISA |
| Dilution range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Protein Name | Anti-Caldesmon antibody |
| Immunogen | Synthesized peptide derived from human Caldesmon around the non-phosphorylation site of S789. |
| Storage Instruction | Store at -20°C, and avoid repeat freeze-thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Human,Mouse,Rat |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 80 kDa |
| Database Links | |
| Alternative Names | Caldesmon antibody CDM antibody CAD antibody CDM antibody |
| Function | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration . |
| Cellular Localization | Cytoplasm, cytoskeleton Cytoplasm, myofibril. On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). |
| Tissue Specificity | High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart. |
| Swiss-Prot Key |