General Information
| Product name | Anti-CAPNS1 Antibody |
|---|---|
| Short Description | Rabbit polyclonal to CAPNS1 |
| Description | This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. |
| Applications | WB,IHC |
| Dilution range | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Protein Name | Anti-CAPNS1 Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 69-268 of human CAPNS1 (NP_001740.1). |
| Storage Instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Isotype | IgG |
| Formulation | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 28.3 kDa |
| Database Links | |
| Alternative Names | CAPNS1Calpain small subunit 1 antibodyCSS1 antibodyCalcium-activated neutral proteinase small subunit antibodyCANP small subunit antibodyCalcium-dependent protease small subunit antibodyCDPS antibodyCalcium-dependent protease small subunit 1 antibodyCalpain regulatory subunitCAPNS1 antibodyCAPN4 antibodyCAPNS |
| Function | Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction |
| Cellular Localization | Cytoplasm |
| Tissue Specificity | |
| Swiss-Prot Key |