Anti-CARD8 Antibody

Rs. 45,619.00
SKU stj22889

General Information

Product name Anti-CARD8 Antibody
Short Description Rabbit polyclonal to CARD8
Description The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CARD8 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CARD8 (NP_003796.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 48.9 kDa
Database Links
Alternative Names CARD8Caspase recruitment domain-containing protein 8 antibodyApoptotic protein NDPP1 antibodyCARD-inhibitor of NF-kappa-B-activating ligand antibodyCARDINAL antibodyDACAR antibodyTumor up-regulated CARD-containing antagonist of CASP9 antibodyTUCANCARD8 antibodyKIAA0955 antibodyNDPP1
Function Inhibits NF-kappa-B activation, May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor, May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases
Cellular Localization Cytoplasm
Tissue Specificity High expression in lung, ovary, testis and placenta, lower expression in heart, kidney and liver, also expressed in spleen, lymph node and bone marrow
Swiss-Prot Key

 

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