Anti-CARM1 Antibody

Rs. 45,619.00
SKU stj22890

General Information

Product name Anti-CARM1 Antibody
Short Description Rabbit polyclonal to CARM1
Description This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9.
Applications WB
Dilution range WB 1:200 - 1:2000
Protein Name Anti-CARM1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 409-608 of human CARM1 (NP_954592.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 65.9 kDa
Database Links
Alternative Names CARM1Histone-arginine methyltransferase CARM1 CARM1 antibodyPRMT4
Function Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability, Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling, During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription, During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C, During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B, Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue, Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors, Also seems to be involved in p53/TP53 transcriptional activation, Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation, Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
Cellular Localization Nucleus, Cytoplasm.
Tissue Specificity Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.
Swiss-Prot Key

 

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