Anti-CAS antibody

Rs. 50,211.00
SKU stj92006

General Information

Product name Anti-CAS antibody
Short Description
Description Rabbit polyclonal to CAS.
Applications WB,IHC,IP,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IP 1:200-500IF 1:200-1:1000ELISA 1:40000
Protein Name Anti-CAS antibody
Immunogen Synthesized peptide derived from human CAS
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 110 kDa
Database Links
Alternative Names Exportin-2 antibody
Exp2 antibody
Cellular apoptosis susceptibility protein antibody
Chromosome segregation 1-like protein antibody
Importin-alpha re-exporter antibody
XPO2 antibody
Function Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular Localization Cytoplasm Nucleus. Shuttles between the nucleus and the cytoplasm.
Tissue Specificity Detected in brain, placenta, ovary, testis and trachea (at protein level) . Widely expressed . Highly expressed in testis and in proliferating cells .
Swiss-Prot Key

 

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