Anti-CASC3 Antibody

Rs. 61,689.00
SKU stj27763

General Information

Product name Anti-CASC3 Antibody
Short Description Rabbit polyclonal to CASC3
Description The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-CASC3 Antibody
Immunogen A synthetic peptide of human CASC3
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 76.3 kDa
Database Links
Alternative Names CASC3Protein CASC3 antibodyCancer susceptibility candidate gene 3 protein antibodyMetastatic lymph node gene 51 protein antibodyMLN 51 antibodyProtein barentsz antibodyBtzCASC3 antibodyMLN51
Function Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs, The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism, The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD), Stimulates the ATPase and RNA-helicase activities of EIF4A3, Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress, Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons, May play a role in mRNA transport, Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions, Binds poly(G) and poly(U) RNA homopolymer.
Cellular Localization Cytoplasm.
Tissue Specificity Widely expressed, overexpressed in breast cancers and metastasis, as well as in gastric cancers.
Swiss-Prot Key

 

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