Anti-CASK Antibody

Rs. 45,619.00
SKU stj22891

General Information

Product name Anti-CASK Antibody
Short Description Rabbit polyclonal to CASK
Description This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-CASK Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CASK (NP_001119526.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 105.1 kDa
Database Links
Alternative Names CASKPeripheral plasma membrane protein CASK antibodyhCASKCASK antibodyLIN2
Function Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking, Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1, Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans, May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4,1
Cellular Localization Nucleus
Tissue Specificity Ubiquitous, expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.
Swiss-Prot Key

 

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