Anti-CASP1 Antibody

Rs. 45,619.00
SKU stj22893

General Information

Product name Anti-CASP1 Antibody
Short Description Rabbit polyclonal to CASP1
Description This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Applications WB,IP
Dilution range WB 1:500 - 1:2000
IP 1:50 - 1:100
Protein Name Anti-CASP1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-311 of human CASP1 (NP_150635.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 45.2 kDa
Database Links
Alternative Names CASP1Caspase-1 antibodyCASP-1CASP1 antibodyIL1BC antibodyIL1BCE
Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes, Important for defense against pathogens, Cleaves and activates sterol regulatory element binding proteins (SREBPs), Can also promote apoptosis, Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive.
Cellular Localization Cytoplasm
Tissue Specificity Expressed in larger amounts in spleen and lung, detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis, no expression in the brain.
Swiss-Prot Key

 

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