Anti-CASP10 Antibody

Rs. 45,619.00
SKU stj22894

General Information

Product name Anti-CASP10 Antibody
Short Description Rabbit polyclonal to CASP10
Description This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CASP10 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 230-505 of human CASP10 (NP_116759.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 59 kDa
Database Links
Alternative Names CASP10Caspase-10 antibodyCASP-10CASP10 antibodyMCH4
Function Involved in the activation cascade of caspases responsible for apoptosis execution, Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner, May participate in the granzyme B apoptotic pathways, Cleaves and activates caspase-3, -4, -6, -7, -8, and -9, Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.
Cellular Localization
Tissue Specificity Detectable in most tissues, lowest expression is seen in brain, kidney, prostate, testis and colon
Swiss-Prot Key

 

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