Anti-CASP3 Antibody

Rs. 45,619.00
SKU stj113694

General Information

Product name Anti-CASP3 Antibody
Short Description Rabbit polyclonal to CASP3
Description This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Caspase-3CASP-3
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 55-160 of human CASP3 (NP_004337.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 31.6 kDa
Database Links
Alternative Names CASP3Caspase-3 antibodyCASP-3CASP3 antibodyCPP32
Function Involved in the activation cascade of caspases responsible for apoptosis execution, At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond, Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain, Cleaves and activates caspase-6, -7 and -9, Involved in the cleavage of huntingtin, Triggers cell adhesion in sympathetic neurons through RET cleavage.
Cellular Localization Cytoplasm
Tissue Specificity Highly expressed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis, also found in many cell lines, highest expression in cells of the immune system
Swiss-Prot Key

 

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