Anti-Casp7 Antibody

Rs. 45,619.00
SKU stj22904

General Information

Product name Anti-Casp7 Antibody
Short Description Rabbit polyclonal to CASP7
Description This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-Casp7 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 24-303 of human Casp7 (NP_001218.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 34.3 kDa
Database Links
Alternative Names CASP7Caspase-7 antibodyCASP-7CASP7 antibodyMCH3
Function Involved in the activation cascade of caspases responsible for apoptosis execution, Cleaves and activates sterol regulatory element binding proteins (SREBPs), Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond, Overexpression promotes programmed cell death
Cellular Localization Cytoplasm
Tissue Specificity Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis, no expression in the brain
Swiss-Prot Key

 

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