Anti-CASP9 Antibody

Rs. 45,619.00
SKU stj29774

General Information

Product name Anti-CASP9 Antibody
Short Description Rabbit polyclonal to CASP9
Description This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-CASP9 Antibody
Immunogen Recombinant protein of human CASP9
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 46.3 kDa
Database Links
Alternative Names CASP9Caspase-9 antibodyCASP-9CASP9 antibodyMCH6
Function Involved in the activation cascade of caspases responsible for apoptosis execution, Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3, Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner, Proteolytically cleaves poly(ADP-ribose) polymerase (PARP)
Cellular Localization
Tissue Specificity Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas, low levels in all other tissues, within the heart, specifically expressed in myocytes.
Swiss-Prot Key

 

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