Anti-Caspase-7 antibody

Rs. 50,211.00
SKU stj90031

General Information

Product name Anti-Caspase-7 antibody
Short Description Rabbit polyclonal to Caspase-7.
Description Caspase-7 is a protein encoded by the CASP7 gene which is approximately 34,2 kDa. Caspase-7 is localised to the cytoplasm. It is involved in the TNFR1 pathway and apoptosis modulation and signalling. It exists as an inactive proenzyme which undergoes proteolytic processing at conserved aspartic residues to produce two subunits that dimerize to form the active enzyme. It is involved in the activation cascade of caspases responsible for apoptosis execution. Caspase-7 is highly expressed in the lung, skeletal muscle, liver, kidney, spleen and heart. Mutations in the CASP7 gene may result in breast adenocarcinoma. stj90031 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-7 protein.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:40000
Protein Name Anti-Caspase-7 antibody
Immunogen Synthesized peptide derived from human Caspase-7
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 34 kDa
Database Links
Alternative Names Caspase-7 antibody
CASP-7 antibody
Apoptotic protease Mch-3 antibody
CMH-1 antibody
ICE-like apoptotic protease 3 antibody
ICE-LAP3 antibody subunit p20 antibody subunit p11 antibody
MCH3 antibody
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
Cellular Localization Cytoplasm.
Tissue Specificity Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
Swiss-Prot Key

 

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