Anti-Catenin-α1 antibody

Rs. 50,211.00
SKU stj92035

General Information

Product name Anti-Catenin-α1 antibody
Short Description
Description Rabbit polyclonal to Catenin-α1.
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-Catenin-α1 antibody
Immunogen Synthesized peptide derived from human Catenin-α1 around the non-phosphorylation site of S641.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 100.071 kDa
Database Links
Alternative Names Catenin alpha-1 antibody
Alpha E-catenin antibody
Cadherin-associated protein antibody
Renal carcinoma antigen NY-REN-13 antibody
Function Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Cellular Localization Isoform 1: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.. Isoform 3: Cell membrane
Tissue Specificity Expressed ubiquitously in normal tissues.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF