Anti-CAV1 Antibody

Rs. 45,619.00
SKU stj28041

General Information

Product name Anti-CAV1 Antibody
Short Description Rabbit polyclonal to CAV1
Description The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CAV1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human CAV1 (NP_001744.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 20.5 kDa
Database Links
Alternative Names CAV1Caveolin-1CAV1 antibodyCAV
Function May act as a scaffolding protein within caveolar membranes, Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity), Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation, Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner, Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway, Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.
Cellular Localization Golgi apparatus membrane
Tissue Specificity Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level), expressed in the brain.
Swiss-Prot Key

 

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