Anti-Caveolin-1 antibody

Rs. 50,211.00
SKU stj92050

General Information

Product name Anti-Caveolin-1 antibody
Short Description
Description Rabbit polyclonal to Caveolin-1.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:20000
Protein Name Anti-Caveolin-1 antibody
Immunogen Synthesized peptide derived from human Caveolin-1 around the non-phosphorylation site of Y14.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 25 kDa
Database Links
Alternative Names CAV1 antibody
CAV antibody
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity . Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation . Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae .
Cellular Localization Golgi apparatus membrane. Peripheral membrane protein. Cell membrane. Peripheral membrane protein. Membrane, caveola Golgi apparatus, trans-Golgi network. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
Tissue Specificity Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.
Swiss-Prot Key

 

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