Anti-CBL Antibody

Rs. 68,577.00
SKU stj70107

General Information

Product name Anti-CBL Antibody
Short Description Goat polyclonal to CBL
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-CBL Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 99.6 kDa
Database Links
Alternative Names CBLE3 ubiquitin-protein ligase CBL CBL antibodyCBL2 antibodyRNF55
Function Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors, Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome, Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling, Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation, Participates in signal transduction in hematopoietic cells, Plays an important role in the regulation of osteoblast differentiation and apoptosis, Essential for osteoclastic bone resorption, The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function, May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3,
Cellular Localization Cytoplasm, Cell membrane,
Tissue Specificity
Swiss-Prot Key

 

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