Anti-Cbl antibody

Rs. 50,211.00
SKU stj92056

General Information

Product name Anti-Cbl antibody
Short Description
Description Rabbit polyclonal to Cbl.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000
Protein Name Anti-Cbl antibody
Immunogen Synthesized peptide derived from human Cbl around the non-phosphorylation site of Y700.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 100 kDa
Database Links
Alternative Names E3 ubiquitin-protein ligase CBL antibody
Casitas B-lineage lymphoma proto-oncogene antibody
Proto-oncogene c-Cbl antibody
RING finger protein 55 antibody
RING-type E3 ubiquitin transferase CBL antibody
Signal transduction protein CBL antibody2 antibody
RNF55 antibody
Function Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Cellular Localization Cytoplasm. Cell membrane. Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Tissue Specificity
Swiss-Prot Key

 

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