General Information
| Product name | Anti-CBP (Acetyl K1535) antibody |
|---|---|
| Short Description | |
| Description | Rabbit polyclonal to Acetyl-CBP (K1535). |
| Applications | WB,IHC,ELISA |
| Dilution range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000 |
| Protein Name | Anti-CBP (Acetyl K1535) antibody |
| Immunogen | Synthesized peptide derived from human CBP around the acetylation site of K1535 |
| Storage Instruction | Store at -20°C, and avoid repeat freeze-thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Human,Mouse,Rat |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 265 kDa |
| Database Links | |
| Alternative Names | CBP (Acetyl K1535) CREB-binding protein antibody CBP antibody |
| Function | Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) . |
| Cellular Localization | Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. |
| Tissue Specificity | |
| Swiss-Prot Key |