Anti-CBX5 Antibody

Rs. 45,619.00
SKU stj114466

General Information

Product name Anti-CBX5 Antibody
Short Description Rabbit polyclonal to CBX5
Description This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Chromobox protein homolog 5Antigen p25Heterochromatin protein 1 homolog alphaHP1 alpha
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human CBX5 (NP_001120794.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 22.2 kDa
Database Links
Alternative Names CBX5Chromobox protein homolog 5 antibodyAntigen p25 antibodyHeterochromatin protein 1 homolog alpha antibodyHP1 alphaCBX5 antibodyHP1A
Function Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression, In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph), Can interact with lamin-B receptor (LBR), This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane, Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Cellular Localization Nucleus.
Tissue Specificity
Swiss-Prot Key

 

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