Anti-CCL21 Antibody

Rs. 45,619.00
SKU stj22930

General Information

Product name Anti-CCL21 Antibody
Short Description Rabbit polyclonal to CCL21
Description This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
Applications IHC
Dilution range IHC 1:50 - 1:100
Protein Name Anti-CCL21 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 24-134 of human CCL21 (NP_002980.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 14.6 kDa
Database Links
Alternative Names CCL21C-C motif chemokine 21 antibody6Ckine antibodyBeta-chemokine exodus-2 antibodySecondary lymphoid-tissue chemokine antibodySLC antibodySmall-inducible cytokine A21CCL21 antibodySCYA21 antibodyUNQ784/PRO1600
Function Inhibits hemopoiesis and stimulates chemotaxis, Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils, Shows preferential activity towards naive T-cells, May play a role in mediating homing of lymphocytes to secondary lymphoid organs, Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4
Cellular Localization Secreted
Tissue Specificity Highly expressed in high endothelial venules of lymph nodes, spleen and appendix, intermediate levels found in small intestine, thyroid gland and trachea, low level expression in thymus, bone marrow, liver, and pancreas, also found in tonsil, fetal heart and fetal spleen
Swiss-Prot Key

 

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