Anti-CCL22 Antibody

Rs. 45,619.00
SKU stj22931

General Information

Product name Anti-CCL22 Antibody
Short Description Rabbit polyclonal to CCL22
Description This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-CCL22 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-93 of human CCL22 (NP_002981.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 10.6 kDa
Database Links
Alternative Names CCL22C-C motif chemokine 22 antibodyCC chemokine STCP-1 antibodyMDC(1-69 antibody antibodyMacrophage-derived chemokine antibodySmall-inducible cytokine A22 antibodyStimulated T-cell chemotactic protein 1CCL22 antibodyMDC antibodySCYA22 antibodyA-152E5.1
Function May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology, Chemotactic for monocytes, dendritic cells and natural killer cells, Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes, Binds to CCR4, Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active
Cellular Localization Secreted
Tissue Specificity Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus, also found in lymph node, appendix, activated monocytes, resting and activated macrophages, lower expression in lung and spleen, very weak expression in small intestine, in lymph node expressed in a mature subset of langerhans' cells (cd1a+ and cd83+), expressed in langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy, expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.
Swiss-Prot Key

 

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