Anti-CCL5 Antibody

Rs. 45,619.00
SKU stj27597

General Information

Product name Anti-CCL5 Antibody
Short Description Rabbit polyclonal to CCL5
Description This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CCL5 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 24-91 of human CCL5 (NP_002976.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 10 kDa
Database Links
Alternative Names CCL5C-C motif chemokine 5 antibodyEoCP antibodyEosinophil chemotactic cytokine antibodySIS-delta antibodySmall-inducible cytokine A5 antibodyT cell-specific protein P228 antibodyTCP228 antibodyT-cell-specific protein RANTESCCL5 antibodyD17S136E antibodySCYA5
Function Chemoattractant for blood monocytes, memory T-helper cells and eosinophils, Causes the release of histamine from basophils and activates eosinophils, May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5, One of the major HIV-suppressive factors produced by CD8+ T-cells, Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV), The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection, The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
Cellular Localization Secreted
Tissue Specificity Expressed in the follicular fluid (at protein level), t-cell and macrophage specific.
Swiss-Prot Key

 

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