Anti-CCNE1 Antibody

Rs. 61,689.00
SKU stj22952

General Information

Product name Anti-CCNE1 Antibody
Short Description Rabbit polyclonal to CCNE1
Description The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
Applications WB,IHC,FC
Dilution range WB 1:500 - 1:1000
IHC 1:20 - 1:50
FC 1:20 - 1:50
Protein Name Anti-CCNE1 Antibody
Immunogen A synthetic peptide of human CCNE1
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 47.1 kDa
Database Links
Alternative Names CCNE1G1/S-specific cyclin-E1CCNE1 antibodyCCNE
Function Essential for the control of the cell cycle at the G1/S (start) transition.
Cellular Localization Nucleus
Tissue Specificity Highly expressed in testis and placenta, low levels in bronchial epithelial cells.
Swiss-Prot Key

 

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