Anti-CD247 Antibody

Rs. 45,619.00
SKU stj22982

General Information

Product name Anti-CD247 Antibody
Short Description Rabbit polyclonal to CD247
Description The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-CD247 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 50-164 of human CD247 (NP_932170.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 18.7 kDa
Database Links
Alternative Names CD247T-cell surface glycoprotein CD3 zeta chain antibodyT-cell receptor T3 zeta chain antibodyCD antigen CD247CD247 antibodyCD3Z antibodyT3Z antibodyTCRZ
Function Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response, When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z, All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain, Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.
Cellular Localization Membrane
Tissue Specificity Cd3z is expressed in normal lymphoid tissue and in peripheral blood mononuclear cells (pbmcs).
Swiss-Prot Key

 

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