Anti-CD274 Antibody

Rs. 45,619.00
SKU stj113753

General Information

Product name Anti-CD274 Antibody
Short Description Rabbit polyclonal to CD274
Description This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:20 - 1:100
Protein Name Programmed cell death 1 ligand 1PD-L1PDCD1 ligand 1Programmed death ligand 1B7 homolog 1B7-H1CD antigen CD274
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 19-238 of human CD274 (NP_054862.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 33.3 kDa
Database Links
Alternative Names CD274Programmed cell death 1 ligand 1 antibodyPD-L1 antibodyPDCD1 ligand 1 antibodyProgrammed death ligand 1 antibodyB7 homolog 1 antibodyB7-H1 antibodyCD antigen CD274CD274 antibodyB7H1 antibodyPDCD1L1 antibodyPDCD1LG1 antibodyPDL1
Function Plays a critical role in induction and maintenance of immune tolerance to self, As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response.
Cellular Localization Cell membrane
Tissue Specificity Highly expressed in the heart, skeletal muscle, placenta and lung, weakly expressed in the thymus, spleen, kidney and liver, expressed on activated t- and b-cells, dendritic cells, keratinocytes and monocytes.
Swiss-Prot Key

 

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