Anti-CD276 Antibody

Rs. 61,689.00
SKU stj22986

General Information

Product name Anti-CD276 Antibody
Short Description Rabbit polyclonal to CD276
Description The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CD276 Antibody
Immunogen A synthetic peptide of human CD276
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 57.2 kDa
Database Links
Alternative Names CD276CD276 antigen antibody4Ig-B7-H3 antibodyB7 homolog 3 antibodyB7-H3 antibodyCostimulatory molecule antibodyCD antigen CD276CD276 antibodyB7H3 antibodyPSEC0249 antibodyUNQ309/PRO352
Function May participate in the regulation of T-cell-mediated immune response, May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells, May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces, Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy, Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses, Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Cellular Localization Membrane
Tissue Specificity Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes, weakly expressed in resting monocytes, expressed in dendritic cells derived from monocytes, expressed in epithelial cells of sinonasal tissue, expressed in extravillous trophoblast cells and hofbauer cells of the first trimester placenta and term placenta.
Swiss-Prot Key

 

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