Anti-CD300f antibody

Rs. 50,211.00
SKU stj92113

General Information

Product name Anti-CD300f antibody
Short Description
Description Rabbit polyclonal to CD300f.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:40000
Protein Name Anti-CD300f antibody
Immunogen Synthesized peptide derived from human CD300f
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 30 kDa
Database Links
Alternative Names CMRF35-like molecule 1 antibody
CLM-1 antibody
CD300 antigen-like family member F antibody
Immune receptor expressed on myeloid cells 1 antibody
IREM-1 antibody
Immunoglobulin superfamily member 13 antibody
IgSF13 antibody
NK inhibitory receptor antibody
CD antigen CD300LF antibody
CD300F antibody
CLM1 antibody
IGSF13 antibody
IREM1 antibody
NKIR antibody
UNQ3105/PRO10111 antibody
Function Acts as an inhibitory receptor for myeloid cells and mast cells . Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis . Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands . May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling . Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 . Inhibits osteoclast formation. Induces macrophage cell death upon engagement .
Cellular Localization Cell membrane
Tissue Specificity Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.
Swiss-Prot Key

 

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