Anti-CD4 Antibody

Rs. 45,619.00
SKU stj114878

General Information

Product name Anti-CD4 Antibody
Short Description Rabbit polyclonal to CD4
Description This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name T-cell surface glycoprotein CD4T-cell surface antigen T4/Leu-3CD antigen CD4
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 26-200 of human CD4 (NP_000607.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 51.1 kDa
Database Links
Alternative Names CD4T-cell surface glycoprotein CD4 antibodyT-cell surface antigen T4/Leu-3 antibodyCD antigen CD4CD4
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Cellular Localization Cell membrane.
Tissue Specificity Highly expressed in t-helper cells, the presence of cd4 is a hallmark of t-helper cells which are specialized in the activation and growth of cytotoxic t-cells, regulation of b cells, or activation of phagocytes, cd4 is also present in other immune cells such as macrophages, dendritic cells or nk cells.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed