Anti-CD63 Antibody

Rs. 45,619.00
SKU stj29913

General Information

Product name Anti-CD63 Antibody
Short Description Rabbit polyclonal to CD63
Description The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-CD63 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 103-203 of human CD63 (NP_001771.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 25.6 kDa
Database Links
Alternative Names CD63CD63 antigen antibodyGranulophysin antibodyLysosomal-associated membrane protein 3 antibodyLAMP-3 antibodyMelanoma-associated antigen ME491 antibodyOMA81H antibodyOcular melanoma-associated antigen antibodyTetraspanin-30 antibodyTspan-30 antibodyCD antigen CD63CD63 antibodyMLA1 antibodyTSPAN30
Function Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades, Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases, Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2, Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2, Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes, Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking, May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Cellular Localization Cell membrane.
Tissue Specificity Detected in platelets (at protein level), dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF