Anti-CD63 antibody

Rs. 50,211.00
SKU stj92137

General Information

Product name Anti-CD63 antibody
Short Description
Description Rabbit polyclonal to CD63.
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-CD63 antibody
Immunogen Synthesized peptide derived from human CD63.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 26 kDa
Database Links
Alternative Names CD63 antigen antibody
Granulophysin antibody
Lysosomal-associated membrane protein 3 antibody
LAMP-3 antibody
Melanoma-associated antigen ME491 antibody
OMA81H antibody
Ocular melanoma-associated antigen antibody
Tetraspanin-30 antibody
Tspan-30 antibody
CD antigen CD63 antibody
MLA1 antibody
TSPAN30 antibody
Function Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Cellular Localization Cell membrane Lysosome membrane Late endosome membrane Endosome, multivesicular body Melanosome Secreted, exosome Cell surface. Also found in Weibel-Palade bodies of endothelial cells . Located in platelet dense granules . Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies .
Tissue Specificity Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Swiss-Prot Key

 

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