Anti-CD68 Antibody

Rs. 50,211.00
SKU stj27466

General Information

Product name Anti-CD68 Antibody
Short Description Rabbit polyclonal to CD68
Description This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-CD68 Antibody
Immunogen A synthetic peptide of human CD68
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 37.4 kDa
Database Links
Alternative Names CD68Macrosialin antibodyGp110 antibodyCD antigen CD68CD68
Function Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions, Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites, Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells
Cellular Localization Isoform Short: Cell membrane
Tissue Specificity Highly expressed by blood monocytes and tissue macrophages, also expressed in lymphocytes, fibroblasts and endothelial cells, expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
Swiss-Prot Key

 

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