General Information
| Product name | Anti-CD74 Antibody |
|---|---|
| Short Description | Rabbit polyclonal to CD74 |
| Description | The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
| Applications | WB,IHC |
| Dilution range | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Protein Name | Anti-CD74 Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 73-232 of human CD74 (NP_004346.1). |
| Storage Instruction | Store at -20℃. Avoid freeze / thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Isotype | IgG |
| Formulation | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 33.5 kDa |
| Database Links | |
| Alternative Names | CD74HLA class II histocompatibility antigen gamma chain antibodyHLA-DR antigens-associated invariant chain antibodyIa antigen-associated invariant chain antibodyIi antibodyp33 antibodyCD antigen CD74CD74 antibodyDHLAG |
| Function | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place, Serves as cell surface receptor for the cytokine MIF |
| Cellular Localization | Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus, trans-Golgi network, Endosome, Lysosome. |
| Tissue Specificity | |
| Swiss-Prot Key |