Anti-CD74 Antibody

Rs. 45,619.00
SKU stj27634

General Information

Product name Anti-CD74 Antibody
Short Description Rabbit polyclonal to CD74
Description The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-CD74 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 73-232 of human CD74 (NP_004346.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 33.5 kDa
Database Links
Alternative Names CD74HLA class II histocompatibility antigen gamma chain antibodyHLA-DR antigens-associated invariant chain antibodyIa antigen-associated invariant chain antibodyIi antibodyp33 antibodyCD antigen CD74CD74 antibodyDHLAG
Function Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place, Serves as cell surface receptor for the cytokine MIF
Cellular Localization Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus, trans-Golgi network, Endosome, Lysosome.
Tissue Specificity
Swiss-Prot Key

 

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