Anti-CD84 Antibody

Rs. 45,619.00
SKU stj28516

General Information

Product name Anti-CD84 Antibody
Short Description Rabbit polyclonal to CD84
Description This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-CD84 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 22-225 of human CD84 (NP_003865.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 38.8 kDa
Database Links
Alternative Names CD84SLAM family member 5 antibodyCell surface antigen MAX.3 antibodyHly9-beta antibodyLeukocyte differentiation antigen CD84 antibodySignaling lymphocytic activation molecule 5 antibodyCD antigen CD84CD84 antibodySLAMF5
Function Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2, Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity), Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process, Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway, May serve as a marker for hematopoietic progenitor cells.
Cellular Localization Cell membrane
Tissue Specificity Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes, expressed in macrophages, b-cells, monocytes, platelets, thymocytes, t-cells and dendritic cells, highly expressed in memory t-cells, expressed in mast cells.
Swiss-Prot Key

 

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