Anti-CDC73 Antibody

Rs. 61,689.00
SKU stj23034

General Information

Product name Anti-CDC73 Antibody
Short Description Rabbit polyclonal to CDC73
Description This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.
Applications WB,IHC,IF,FC
Dilution range WB 1:500 - 1:1000
IHC 1:20 - 1:50
IF 1:20 - 1:50
FC 1:20 - 1:50
Protein Name Anti-CDC73 Antibody
Immunogen A synthetic peptide of human CDC73
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 60.6 kDa
Database Links
Alternative Names CDC73Parafibromin antibodyCell division cycle protein 73 homolog antibodyHyperparathyroidism 2 proteinCDC73 antibodyC1orf28 antibodyHRPT2
Function Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways, May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression, Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency, PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1, PAF1C is required for transcription of Hox and Wnt target genes, PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1
Cellular Localization Nucleus
Tissue Specificity Found in adrenal and parathyroid glands, kidney and heart.
Swiss-Prot Key

 

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