Anti-CDH1 Antibody

Rs. 50,211.00
SKU stj27464

General Information

Product name Anti-CDH1 Antibody
Short Description Mouse monoclonal to CDH1
Description This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Applications IHC
Dilution range IHC 1:500 - 1:2000
Protein Name Anti-CDH1 Antibody
Immunogen Recombinant protein of human CDH1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Mouse
Clonality Monoclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 97.5 kDa
Database Links
Alternative Names CDH1Cadherin-1 antibodyCAM 120/80 antibodyEpithelial cadherin antibodyE-cadherin antibodyUvomorulin antibodyCD antigen CD324CDH1 antibodyCDHE antibodyUVO
Function Cadherins are calcium-dependent cell adhesion proteins , Has a potent invasive suppressor role, It is a ligand for integrin alpha-E/beta-7.
Cellular Localization Cell junction
Tissue Specificity Non-neural epithelial tissues
Swiss-Prot Key

 

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