Anti-CDK12 Antibody

Rs. 45,619.00
SKU stj117094

General Information

Product name Anti-CDK12 Antibody
Short Description Rabbit polyclonal to CDK12
Description
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Cyclin-dependent kinase 12
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 80-290 of human CDK12 (NP_057591.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 164.2 kDa
Database Links
Alternative Names CDK12Cyclin-dependent kinase 12 CDK12 antibodyCRK7 antibodyCRKRS antibodyKIAA0904
Function Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation, Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability, Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2', Required for RNA splicing, possibly by phosphorylating SRSF1/SF2, Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Cellular Localization Nucleus, Nucleus speckle.
Tissue Specificity Ubiquitously expressed.
Swiss-Prot Key

 

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