Anti-CDK5R1 Antibody

Rs. 61,689.00
SKU stj23059

General Information

Product name Anti-CDK5R1 Antibody
Short Description Rabbit polyclonal to CDK5R1
Description The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Applications WB,IHC
Dilution range WB 1:200 - 1:500
IHC 1:50 - 1:100
Protein Name Anti-CDK5R1 Antibody
Immunogen A synthetic peptide of human CDK5R1
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 34.1 kDa
Database Links
Alternative Names CDK5R1Cyclin-dependent kinase 5 activator 1 antibodyCDK5 activator 1 antibodyCyclin-dependent kinase 5 regulatory subunit 1 antibodyTPKII regulatory subunitCDK5R1 antibodyCDK5R antibodyNCK5A
Function p35 is a neuron specific activator of CDK5, The complex p35/CDK5 is required for neurite outgrowth and cortical lamination, Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling, Activator of TPKII, The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Cellular Localization Cyclin-dependent kinase 5 activator 1, p35: Cell membrane, Cyclin-dependent kinase 5 activator 1, p25: Nucleus, Cytoplasm, perinuclear region.
Tissue Specificity Brain and neuron specific
Swiss-Prot Key

 

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