Anti-CDK6 Antibody

Rs. 45,619.00
SKU stj23062

General Information

Product name Anti-CDK6 Antibody
Short Description Rabbit polyclonal to CDK6
Description The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-CDK6 Antibody
Immunogen A synthetic peptide of human CDK6
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 36.9 kDa
Database Links
Alternative Names CDK6Cyclin-dependent kinase 6 CDK6 antibodyCDKN6
Function Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation
Cellular Localization Cytoplasm, Nucleus, Cell projection, ruffle, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Tissue Specificity Expressed ubiquitously, accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of langerhans, and neuroblastomas, reduced levels in differentiating cells.
Swiss-Prot Key

 

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