Anti-CDK7 Antibody

Rs. 57,098.00
SKU stj28889

General Information

Product name Anti-CDK7 Antibody
Short Description Mouse monoclonal to CDK7
Description The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
Applications WB,IHC,IP
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IP 1:20- 1:50
Protein Name Anti-CDK7 Antibody
Immunogen Recombinant protein of human CDK7
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Mouse
Clonality Monoclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 39 kDa
Database Links
Alternative Names CDK7Cyclin-dependent kinase 7 CDK7 antibodyCAK antibodyCAK1 antibodyCDKN7 antibodyMO15 antibodySTK1
Function Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription, Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle, Each different complex controls a specific transition between 2 subsequent phases in the cell cycle, Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation), CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11, CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression, CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts, Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA, Its expression and activity are constant throughout the cell cycle, Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53
Cellular Localization Nucleus, Cytoplasm, Cytoplasm, perinuclear region.
Tissue Specificity Ubiquitous
Swiss-Prot Key

 

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