Anti-CDKN1A Antibody

Rs. 57,098.00
SKU stj29794

General Information

Product name Anti-CDKN1A Antibody
Short Description Rabbit polyclonal to CDKN1A
Description This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.
Applications WB,IHC,IP
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IP 1:20 - 1:50
Protein Name Anti-CDKN1A Antibody
Immunogen A synthetic peptide of human CDKN1A
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 18.1 kDa
Database Links
Alternative Names CDKN1ACyclin-dependent kinase inhibitor 1 antibodyCDK-interacting protein 1 antibodyMelanoma differentiation-associated protein 6 antibodyMDA-6 antibodyp21CDKN1A antibodyCAP20 antibodyCDKN1 antibodyCIP1 antibodyMDA6 antibodyPIC1 antibodySDI1 antibodyWAF1
Function May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage, Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression, Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1, At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex, Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding.
Cellular Localization Cytoplasm, Nucleus
Tissue Specificity Expressed in all adult tissues, with 5-fold lower levels observed in the brain
Swiss-Prot Key

 

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