Anti-CDKN1B Antibody

Rs. 45,619.00
SKU stj23073

General Information

Product name Anti-CDKN1B Antibody
Short Description Rabbit polyclonal to CDKN1B
Description This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
Applications WB
Dilution range WB 1:200 - 1:1000
Protein Name Anti-CDKN1B Antibody
Immunogen Recombinant protein of human CDKN1B
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 22.1 kDa
Database Links
Alternative Names CDKN1BCyclin-dependent kinase inhibitor 1B antibodyCyclin-dependent kinase inhibitor p27 antibodyp27Kip1CDKN1B antibodyKIP1
Function Important regulator of cell cycle progression, Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA , Involved in G1 arrest, Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes, Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation, Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Cellular Localization Nucleus, Cytoplasm, Endosome, this leads to lysosomal degradation (By similarity).
Tissue Specificity Expressed in all tissues tested, highest levels in skeletal muscle, lowest in liver and kidney
Swiss-Prot Key

 

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