Anti-CDKN2A Antibody

Rs. 57,098.00
SKU stj23077

General Information

Product name Anti-CDKN2A Antibody
Short Description Mouse monoclonal to CDKN2A
Description This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:1000
IHC 1:20 - 1:100
Protein Name Anti-CDKN2A Antibody
Immunogen Recombinant protein of human CDKN2A
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Mouse
Clonality Monoclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 16.5 kDa
Database Links
Alternative Names CDKN2ACyclin-dependent kinase inhibitor 2A antibodyCyclin-dependent kinase 4 inhibitor A antibodyCDK4I antibodyMultiple tumor suppressor 1 antibodyMTS-1 antibodyp16-INK4a antibodyp16-INK4 antibodyp16INK4ACDKN2A antibodyCDKN2 antibodyMTS1
Function Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6, This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Cellular Localization Cytoplasm
Tissue Specificity Widely expressed but not detected in brain or skeletal muscle, isoform 3 is pancreas-specific.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed