Anti-CDKN2B Antibody

Rs. 45,619.00
SKU stj27652

General Information

Product name Anti-CDKN2B Antibody
Short Description Rabbit polyclonal to CDKN2B
Description This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CDKN2B Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human CDKN2B (NP_004927.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 14.7 kDa
Database Links
Alternative Names CDKN2BCyclin-dependent kinase 4 inhibitor B antibodyMultiple tumor suppressor 2 antibodyMTS-2 antibodyp14-INK4b antibodyp15-INK4b antibodyp15INK4BCDKN2B antibodyMTS2
Function Interacts strongly with CDK4 and CDK6, Potent inhibitor, Potential effector of TGF-beta induced cell cycle arrest
Cellular Localization Cytoplasm.
Tissue Specificity Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.
Swiss-Prot Key

 

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