Anti-CELF1 Antibody

Rs. 45,619.00
SKU stj29928

General Information

Product name Anti-CELF1 Antibody
Short Description Rabbit polyclonal to CELF1
Description Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB
Dilution range WB 1:200 - 1:2000
Protein Name Anti-CELF1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 108-483 of human CELF1 (NP_941989.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 52.1 kDa
Database Links
Alternative Names CELF1CUGBP Elav-like family member 1 antibodyCELF-1 antibody50 kDa nuclear polyadenylated RNA-binding protein antibodyBruno-like protein 2 antibodyCUG triplet repeat RNA-binding protein 1 antibodyCUG-BP1 antibodyCUG-BP- and ETR-3-like factor 1 antibodyDeadenylation factor CUG-BP antibodyEmbryo deadenylation element-binding protein homolog antibodyEDEN-BP homolog antibodyRNA-binding protein BRUNOL-2CELF1 antibodyBRUNOL2 antibodyCUGBP antibodyCUGBP1 antibodyNAB50
Function RNA-binding protein implicated in the regulation of several post-transcriptional events, Involved in pre-mRNA alternative splicing, mRNA translation and stability, Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing, Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition, Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs, Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB, Promotes exclusion of exon 11 of the INSR pre-mRNA, Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast, Increases translation and controls the choice of translation initiation codon of CEBPB mRNA, Increases mRNA translation of CEBPB in aging liver (By similarity), Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3, Mediates rapid cytoplasmic mRNA deadenylation, Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation, Required for completion of spermatogenesis (By similarity), Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs), Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA, Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs, Binds to the IR RNA, Binds to the 5'-region of CDKN1A and CEBPB mRNAs, Binds with the 5'-region of CEBPB mRNA in aging liver, May be a specific regulator of miRNA biogenesis, Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA.
Cellular Localization Nucleus.
Tissue Specificity Ubiquitous.
Swiss-Prot Key

 

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