Anti-CENP-A antibody

Rs. 50,211.00
SKU stj92218

General Information

Product name Anti-CENP-A antibody
Short Description
Description Rabbit polyclonal to CENP-A.
Applications IHC,IF,ELISA
Dilution range IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000
Protein Name Anti-CENP-A antibody
Immunogen Synthesized peptide derived from human CENP-A around the non-phosphorylation site of S7.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 15.991 kDa
Database Links
Alternative Names Histone H3-like centromeric protein A antibody
Centromere autoantigen A antibody
Centromere protein A antibody
Function Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes . Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore . The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 . May serve as an epigenetic mark that propagates centromere identity through replication and cell division . Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis .
Cellular Localization Nucleus Chromosome, centromere, kinetochore Chromosome, centromere. Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height . Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location .
Tissue Specificity
Swiss-Prot Key

 

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