Anti-CES1 Antibody

Rs. 45,619.00
SKU stj23100

General Information

Product name Anti-CES1 Antibody
Short Description Rabbit polyclonal to CES1
Description This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-CES1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 287-566 of human CES1 (NP_001257.4).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 62.5 kDa
Database Links
Alternative Names CES1Liver carboxylesterase 1 antibodyAcyl-coenzyme A:cholesterol acyltransferase antibodyACAT antibodyBrain carboxylesterase hBr1 antibodyCarboxylesterase 1 antibodyCE-1 antibodyhCE-1CES1 antibodyCES2 antibodySES1
Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs, Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester, Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine, Catalyzes the transesterification of cocaine to form cocaethylene, Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
Cellular Localization Endoplasmic reticulum lumen
Tissue Specificity Expressed predominantly in liver with lower levels in heart and lung.
Swiss-Prot Key

 

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