Anti-CHMP2B Antibody

Rs. 45,619.00
SKU stj115372

General Information

Product name Anti-CHMP2B Antibody
Short Description Rabbit polyclonal to CHMP2B
Description This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Charged multivesicular body protein 2bCHMP2.5Chromatin-modifying protein 2bCHMP2bVacuolar protein sorting-associated protein 2-2Vps2-2hVps2-2
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human CHMP2B (NP_054762.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 23.9 kDa
Database Links
Alternative Names CHMP2BCharged multivesicular body protein 2b antibodyCHMP2.5 antibodyChromatin-modifying protein 2b antibodyCHMP2b antibodyVacuolar protein sorting-associated protein 2-2 antibodyVps2-2 antibodyhVps2-2CHMP2B antibodyCGI-84
Function Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs, MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids, The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes, ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released, The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses), ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4
Cellular Localization Cytoplasm, cytosol
Tissue Specificity Widely expressed, expressed in brain, heart, skeletal muscle, spleen, kidney, liver, small intestine, pancreas, lung, placenta and leukocytes, in brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal chord, occipital lobe, frontal lobe, temporal lobe and putamen.
Swiss-Prot Key

 

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